Could Fish Waste Prove a Good Source of a Popular Health Food Ingredient?

Aggrecan, a major part of proteoglycan (PG) possessing chondroitin sulfate (CS) in cartilaginous tissues, has turn into progressively popular as an component in wellness foods. In point, proteoglycans from salmon nasal cartilage show organic homes this sort of as antiaging, inhibition of angiogenesis, and attenuation of inflammatory responses. Commercially available chondroitin sulfate proteoglycans (CSPGs) have only been geared up from salmon nasal cartilage. Despite the fact that the head cartilage was identified in other edible bony fishes, there is small data on the composition of main proteins and their CS structures in the head cartilage.

Now, in a new examine released in the Worldwide Journal of Biology Macromolecules, a group of scientists led by Associate Professor Kyohei Higashi of Tokyo University of Science, and Dr. Naoshi Dohmae and Dr. Takehiro Suzuki of the RIKEN Center for Sustainable Useful resource Science tackles this concern. “We observed that composition of PGs and their CS framework in the skull of the Siberian sturgeon and Russian sturgeon were being related to that in the salmon nasal cartilage,” experiences Dr. Higashi. The fishes for the study have been provided by Mr. Atsuhi Nakamura from Miyazaki Prefectural Fisheries Research Institute. This research was designed out there on the internet on March 23, 2022 and was revealed in Volume 208 of the journal on Could 31, 2022.

All the fishes examined contained plentiful CSPGs in the head cartilage. Extensive examination of CS structure in PGs derived from 10 bony fishes disclosed that the framework of CS derived from Perciformes were being similar to that of CS derived from cartilage of terrestrial animals. On the other hand, the construction of CS from skull of sturgeons was related to that of CS from salmon nasal cartilage. In addition, they also located that aggrecan, a big CSPG in the cartilaginous tissue, was conserved in 10 bony fishes. In fact, the aggrecan protein from LOC117428125 and LOC117964296 genes registered in the National Center for Biotechnology Information and facts databases was found to be considerable in the skull of sturgeons. Also, compositions of other PGs, collagens, and matrix proteins in the cranium of sturgeons have been equivalent to that of salmon nasal cartilage.

Elaborating on the results of this analyze, Dr. Kyohei Higashi states, “Head cartilage from bony fishes is an underutilized useful resource and is normally discarded immediately after food items processing. The PGs, especially from the sturgeon, are similar in CS composition to the salmon nasal cartilage, exhibiting that the sturgeon has a whole lot of probable to be an alternate resource of CSPGs for overall health meals formulations.”

Reference: Shionoya K, Suzuki T, Takada M, et al. In depth analysis of chondroitin sulfate and aggrecan in the head cartilage of bony fishes: Identification of proteoglycans in the head cartilage of sturgeon. Int J Bio Macromol. 2022208:333-342. doi:10.1016/j.ijbiomac.2022.03.125

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